Efficacy and mechanism of traditional Chinese medicine in relieving antibiotic-resistant bacterial diarrhea in children: study protocol for a randomized controlled trial

Abstract Background Bacterial infection is an important cause of diarrhea in children, potentially leading to malnutrition, growth and development disorders, even death. Antibiotic abuse resistance are widespread problems worldwide, especially China. We therefore designed a study evaluate the clinical efficacy mechanism traditional Chinese medicine alleviating effects antibiotic childhood bacterial enhancing sensitivity pathogenic bacteria antibiotics. Methods This randomized, double-blind, placebo-controlled trial has completed ChiCTR registration. The will randomly divide 120 children who meet inclusion criteria into three groups: experimental group 1 (basic treatment + Gegen Qinlian decoction granules Erbai drink placebo), 2 control placebo placebo). main indicators be use rate cure rate, secondary time intervention, effective course determined after 5 days. following physical chemical measured: routine blood parameters, procalcitonin, C-reactive protein, electrocardiogram, liver kidney function, electrolytes, urinalysis, stool analysis, culture (including drug sensitivity). Discussion results this may provide objective basis for managing antibiotic-resistant formulating relevant guidelines, demonstrating reducing Trial registration Clinical Registry ChiCTR1900027915 . Last refreshed on December 4, 2019.